Research Article | Volume: 6, Issue: 4, April, 2016

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C supplementation on coronary risk biomarkers in patients with hypercholesterolaemia with moderate coronary risk

Muhamed T. Osman,  Azlina Abdul Razak,  Huzaimi Haron,  Thuhairah Rahman ,  Suhaila Muid,  Tengku Saifudin Tengku Ismail,  Anis Safura Ramli ,  Sushil Kumar Vasudevan ,  Hapizah Nawawi   
Muhamed T. Osman3, Azlina Abdul Razak1, Huzaimi Haron1, Thuhairah Rahman1 & 2, Suhaila Muid1, Tengku Saifudin Tengku Ismail1, Anis Safura Ramli1 & 2, Sushil Kumar Vasudevan1 & 2, Hapizah Nawawi1 & 2

1Faculty of Medicine, Universiti Teknologi MARA (UiTM), Sg. Buloh, Selangor, Malaysia.

2Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), UiTM Malaysia.

3Faculty of Medicine and Defense Health, National Defense University of Malaysia (UPNM), Kem Sungai Besi, Kuala Lumpur, Malaysia.

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60418
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Abstract

This study was a prospective clinical trial to investigate the effects of adding combined tocotrienol-tocopherol mixed fraction (TTMF) and vitamin C (TTMF+C) supplementation on coronary biomarkers in non-statin and statin treated patients with hypercholesterolaemia (HC) with moderate coronary risk. A total of 35 patients were randomised at baseline into one of two groups, (G1) TTMF+C (320mg TTMF plus 500mg vitamin C) alone daily and (G2) TTMF+C (320mg TTMF plus 500mg vitamin C) plus atorvastatin 10 mg daily. The entire supplementation were taken for 12 months. Fasting serum samples were taken at baseline, 2weeks, 3months, 6months and 12months post-randomisation and analysed for inflammatory biomarkers; high sensitivity C- reactive protein (hsCRP) and interleukin-6 (IL6). Combination of TTMF and vitamin C supplementation leads to neutral effects on lipid profiles and inflammation; with no added benefit in statin-treated HC patients with moderate coronary risk. This neutral effects may be attributed to the tocopherol composition in TTMF which could possibly attenuate any potential beneficial effects of tocotrienols. Clinical studies using pure tocotrienols in the absence of tocopherols would further confirm this.


Keyword:     Hypercholesterolaemia Tocopherol-Tocotrienol mixed fraction vitamin E Vitamin C Moderate Coronary Risk Antioxidants.

Citation:

Osman MT, Rahman T, Azlina AR, Muid S, Ismail TS, Kumar S , Haron H, Ramli AS and Nawawi H. Effects of adding tocotrienoltocopherol mixed fraction and vitamin C supplementation on coronary risk biomarkers in patients with hypercholesterolaemia with moderate coronary risk. J App Pharm Sci, 2016; 6 (04): 133- 138.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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