Research Article | Volume: 6, Issue: 4, April, 2016

Comparison of development methods based on UV/VIS spectrophotometry and ICP OES for the determination of iodine in pharmaceuticals

Amanda Ramos Della Fonte Vitor de Araújo Freitas Rosangela Cristina Barthus   

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60404

In this study, methods based on UV-Vis spectrophotometry (Sandell-Kolthoff reaction) and inductively coupled plasma optical emission spectrometry (ICP OES) were developed in order to determine iodine in pharmaceuticals. A simple preparation of samples, which consisted in the solubilization by means of ultrasound, was performed using pure water as solvent. The developed analytical methods were validated employing limit of detection, precision and accuracy. The recovery range is 101.0% - 104.0% for the expectorant solutions, and 98.0% - 102.0% for the supplements using the ICP OES technique. For the UV-Vis spectrophotometric method, the recovery range is 96.0% - 98.0% for the expectorant solutions, and 96.0% - 98.3% for the supplements. These methods are simple and accessible, and might be used in the pharmaceutical field.

Keyword:     UV-Vis spectrophotometry Sandell-Kolthoff reaction ICP OES iodine.


Fonte ARD, Freitas VA, Barthus RC. Comparison of development methods based on UV-VIS spectrophotometry and ICP OES for the determination of iodine in pharmaceutical. J App Pharm Sci, 2016; 6 (04): 022-027.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics

360 Absract views 19 PDF Downloads 379 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required
Similar Articles