Research Article | Volume: 6, Issue: 4, April, 2016

Chemical constituents and cytotoxic effect from the barks of Goniothalamus chinensis Merr. & Chun. growing in Vietnam

Loi Vu Duc Tung Bui Thanh Hai Nguyen Thanh Vung Nguyen Tien   

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60401
Abstract

Goniothalamus chinensis Merr. & Chun is a medicinal plant which has cytotoxicity, antitumor, antifungal, antimalaria and antituberculosis and antioxidant activity. The styryl-lactone, alkaloid and acetogenin are the main group compounds in species of Goniothalamus. In this study, we aimed to investigate phytochemical and cytotoxic effect of compounds from bark of Goniothalamus chinensis Merr. & Chun. The bark of Goniothalamus chinensis Merr. & Chun grown in Vietnam was extracted by methanol. Three compounds were isolated using on Sephadex LH-20 and preparative glass-backed TLC plates. The compound's structure were characterized on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published in literatures. The cytotoxicity of three compounds was evaluated against four cancer cell lines: epithelial cancer (KB), liver (Hep G2); breast cancer (MCF-7) and lung (LU-1). We have been isolated three compounds. Their structures were identified as Goniothalamin (1), Aristolactam BII (2), 3-Methyl-1H-benz[f]indole-4,9-dione (3). Isolated compounds were tested cytotoxic activity against different cancer cell lines. The compound 1 demonstrated the highest potency against the epithelial cancer cell line with an IC50 of 4.18 ± 0.60µg/mL. Other compounds have weak cytotoxic activity.


Keyword:     Goniothalamus chinensis Merr. & Chun cytotoxicity cancer cell line.


Citation:

Duc LV, Thanh TB, Thanh HN, Tien VN. Chemical constituents and cytotoxic effect from the barks of Goniothalamus chinensis Merr. & Chun. growing in Vietnam. J App Pharm Sci, 2016; 6 (04): 001-005.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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