Research Article | Volume: 6, Issue: 3, March, 2016

Effect of acute and chronic treatment of Cyclosporin A on liver and kidney functions in rats

Ata Sedik Ibrahim ElsayedMohamed Fathy Farag BayomyAzab Elsayed Azab   

Open Access   

Published:  Mar 30, 2016

DOI: 10.7324/JAPS.2016.60320
Abstract

Cyclosporin A is a compound widely used as an immunosuppressive drug, particularly, in case of kidney transplantation to prevent rejection of transplanted organ. This study aimed to investigate the bad side effect of acute and chronic treatment with cyclosporin A on liver and kidneys by measuring liver enzymes and kidney function tests in serum. Male rats were used as experimental model in this study. The results of this study concluded that, chronic treatment with cycloosprin A leads to increase in serum urea, creatinine, and uric acid significantly compared to control, also, ALT and Alkaline phosphatase activities in serum were increased by chronic administration of cyclosporine A for four weeks. Decrease of serum albumin and total protein were observed significantly compared to control groups.


Keyword:     Cyclosporin AKidneyLiver.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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