Research Article | Volume: 6, Issue: 2, February, 2016

Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Laila H. Emaraa Ahmed A. El-Ashmawya Nesrin F. Tahaa Khaled A. El-Shaffeib El-Sayed M. Mahdeyb Heba K. Elkhollyc   

Open Access   

Published:  Feb 27, 2016

DOI: 10.7324/JAPS.2016.60205

This study explored the effect of nano-crystalline cellulose (NCC) on Meloxicam (MX) solid dispersion (SD) prepared by co-grinding technique compared to micro-crystalline cellulose (MCC) in presence of lactose. MX-tablets were prepared by direct compression of different co-ground SDs or physical mixtures. The solubility, dissolution, SEM and DSC of different preparations were studied. Flow-through cell apparatus (FTC) was used to study the dissolution of MX from tablets at pH 7.4. Generally, the results revealed that increasing NCC loadings showed a direct increase in both the solubility and dissolution of MX. MCC did not improve either the solubility or the dissolution of MX in the physical mixture, while, co-grinding dramatically decreased the dissolution rate of MX. It was interesting to find that grinding of MX-powder alone or in a mixture with lactose highly increased MX solubility and dissolution. SEM as well as DSC were found to be very good tools, without a single exception, to describe the observed solubility and dissolution of MX in these proposed preparations. SEM-images showed the particle size reduction upon grinding or co-grinding techniques. While DSC-data proved that the crystalline structure of MX has been changed to an amorphous state.

Keyword:     Co-grinding solid dispersion flow-through cell apparatus water insoluble drug micro-crystalline cellulose scanning electron microscope differential scanning calorimetry.


Emara LH, El-Ashmawy AA, Taha NF, El-Shaffei KA, Mahdey EM, El-kholly HK. Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam. J App Pharm Sci, 2016; 6 (02): 032-043.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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