Short Communication | Volume: 6, Issue: 1, January, 2016

Phaleria macrocarpa Fruits Methanolic Extract Reduces Blood Pressure and Blood Glucose in Spontaneous Hypertensive Rats (SHR)

Dzulsuhaimi Daud Nur ‘Amirah Badruzzaman Norrizah Jaafar Sidik Alene Tawang   

Open Access   

Published:  Jan 26, 2016

DOI: 10.7324/JAPS.2016.600126
Abstract

Methanolic extract of Phaleria macrocarpa fruits was evaluated for the anti-hypertensive and anti-hyperglycaemic capacity. For a period of three weeks, 18 male young Spontaneous Hypertensive Rats (SHR) were divided into three experimental groups and received commercial rat pellets as their maintenance diet. At the same duration, SHR in Group 1 received 2 ml/kg/day of distilled water and served as a negative control. Meanwhile, SHR in Group 2 and Group 3 received 0.5 mg/kg/day of Telmisartan (positive control) and 500 mg/kg/day P. macrocarpa fruits methanolic extract, respectively. Bodyweight, arterial blood pressure and blood glucose were measured on a weekly basis. All SHR showed significant increased (p<0.05) in their bodyweight but did not differ significantly (p>0.05) between groups. Blood pressure and blood glucose significantly decreased (p<0.05) in SHR treated with Telmisartan and P. macrocarpa compared to negative control. These results lead us to conclude that P. macrocarpa fruits methanolic extract exhibit anti-hypertensive and anti-hyperglycaemic activities.


Keyword:     Phaleria macrocarpa spontaneous hypertensive rats blood glucose blood pressure.


Citation:

Daud D, Badruzzaman N, Sidik NJ, Tawang A. Phaleria macrocarpa Fruits Methanolic Extract Reduces Blood Pressure and Blood Glucose in Spontaneous Hypertensive Rats (SHR). J App Pharm Sci, 2016; 6 (01): 158-161.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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