Research Article | Volume: 5, Issue: 12, December, 2015

Controlled Release of Drugs from Cellulosic Wound Bandage Using Silica Microsphere as Drug Encapsulator Module

Ahmed G. Hassabo Amina L. Mohamed Ahmed A. Nada Nabil Y. Abou Zeid   

Open Access   

Published:  Dec 27, 2015

DOI: 10.7324/JAPS.2015.501211
Abstract

Controlled-drug-releasing materials show promising applications in medicinal bandages. In addition, one could incorporate drugs to make such bandages more versatile. During this context, silica microparticles were synthesized, during presence of different drugs namely sodium diclofenac, linoleic acid and recienoleic acid. The morphological characterization shows formation of monodispersed, silica microparticles. FT-IR spectroscopy provided the interaction of the drug molecule at its hydroxide (OH) site with oxygen ions on the silica surface. UV–vis spectroscopy showed persistence of the different drugs signature, especially its R group, confirming its antimicrobial activity even after conjugation. Using zone-of-inhibition studies, the antimicrobial studies were done on two microorganisms, namely, Staphylococcus aureus and Escherichia coli. However, the encapsulator module showed controlled release of all drugs for the duration of 48 h. This work demonstrated an effective protocol to prepare antimicrobial patches for controlled drug delivery.


Keyword:     Controlled-drug-releasing silica microparticles sodium diclofenac linoleic acid and ricinoleic acid.


Citation:

Hassabo AG, Mohamed AL, Nada AA and Abou Zeid NY. Controlled Release of Drugs from Cellulosic Wound Bandage Using Silica Microsphere as Drug Encapsulator Module., J App Pharm Sci, 2015; 5 (12): 067-073.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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