Research Article | Volume: 5, Issue: 12, December, 2015

Synthesis of Novel Hydrogels based Poly(4-Hydroxyphenylazo-3-N-(4-hydroxyphenyl)maleimide) for Specific Colon Delivery of Chemotherapeutic Agent

P. Rama Subba Reddy,  K.S.V. Krishna Rao ,  K. Madhusudana Rao,  N. Sivagangi Reddy   
P. Rama Subba Reddy1, K.S.V. Krishna Rao1 & 2, K. Madhusudana Rao3, N. Sivagangi Reddy1

1Polymer Biomaterial Design and Synthesis Laboratory, Department of Chemistry, Yogi Vemana University, Kadapa. Andhra Pradesh, India.

2Department of Chemical Engineering and Material Science,Wayne State University, Detroit, MI, USA.

3Nano Information Materials Laboratory, Department of Polymer Science and Engineering, Pusan National University, Busan, South Korea.

Open Access   

Published:  Dec 27, 2015

DOI: 10.7324/JAPS.2015.501204
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Abstract

In recent years azo functionalized polymeric hydrogels are very interesting; it is due to their promising applications in various fields especially in the colon drug delivery. 4-Hydroxyphenylazo-3-N-(4-hydroxyphenyl) maleimide (HPM) was synthesized and used for development of hydrogels by free radical polymerization with acrylamide (Am) and N,N-methylene bis acrylamide. Synthesized poly(Am-co-HPM) (PAH) hydrogels were used for encapsulation of 5-fluorouracil (5-FU) an anticancer drug. Structural, thermal, morphological and drug distribution of PAH hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction techniques, respectively. Maximum percentage of encapsulation efficiency i.e. 78.25±1.3 was observed for AZ1 PAH hydrogels. 5-FU release studies were performed by in vitro method in simulated gastro intestinal fluids (pH 1.2 & 7.4). To support the 5-FU release mechanism from PAH hydrogels, swelling and deswelling kinetics were studied in doubly distilled water.


Keyword:     Hydrogels Azo compounds 5-Fluorouracil Colon Drug Delivery.

Citation:

Reddy PRS, Krishna Rao KSV, Rao KM, Reddy NS. Synthesis of Novel Hydrogels based Poly (4-Hydroxyphenylazo-3-N-(4- hydroxyphenyl)maleimide) for Specific Colon Delivery of Chemotherapeutic Agent. J App Pharm Sci, 2015; 5 (12): 021-028.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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