Research Article | Volume: 5, Issue: 11, November, 2015

Protective Effect of Helix aspersa Extract against Spleen and Liver Injuries Induced by N-Nitroso Methyl Urea in Mice

Ibtissem EL OUAR Hajer ATOUI Ihcène DRAA Cherifa AGGOUNE Dalila NAIMI   

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501119

Objective: This study was carried out to investigate the protective effect of an aqueous extract, from the garden snail Helix aspersa (Mollusca, pulmonate), against N-nitrosomethylurea (NMU) induced damage in mice. Methods: Haematoxylin/ Eosin based histology was performed to evaluate the morphological changes in liver and spleen.

Results: our results show that NMU causes different damages in liver and spleen. It induces alterations of blood system of the two organs with the apparition of hemangioma. The histological assessment shows that H. aspersa extract markedly reduces the damage induced by the carcinogen and preserved the histo-architecture of these tissues. Furthermore, histopathological finding demonstrates that H. aspersa extract increase immune system activity through the stimulation of immune cell penetration in liver and differentiation of macrophages into foreign body giant cells.

Conclusion: These results suggest that H. aspersa extract acts as a potent hepatic and spleen protective agent against NMU carcinogenesis.

Keyword:     N-nitrosomethylurea carcinogenesis. Helix aspersa aqueous extract.


Ibtissem EL OUAR, Ihcène DRAA, Hajer ATOUI, Cherifa AGGOUNE, Dalila NAIMI. Protective Effect of Helix Aspersa Extract Against Spleen and Liver Injuries Induced by N-Nitroso Methyl Urea in Mice. J App Pharm Sci, 2015; 5 (11): 113-116.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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