Research Article | Volume: 5, Issue: 11, November, 2015

Tumor Necrosis Factor Receptor 2: Its Clinical Significance and Clinicopathologic Correlation in acute leukemias

Nabila El Kramani ,  Nehal M Elsherbiny,  Amal M El-Gayar,  Mohamed A. Ebrahim,  Mohammed M H Al-Gayyar   
Nabila El Kramani1 & 2, Nehal M Elsherbiny1, Amal M El-Gayar1, Mohamed A. Ebrahim3, Mohammed M H Al-Gayyar1 & 4

1Department of Clinical Biochemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt.

2Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Egypt.

3Medical Oncology Unit, Oncology Center, Mansoura University.

4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.

Open Access   

Published:  Nov 27, 2015

DOI: 10.7324/JAPS.2015.501113
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Abstract

Objectives: To measure plasma concentrations of Tumor Necrosis Factor Receptor 2 (TNFR2) in patients with acute leukemia, and to correlate the results with clinical features.

Material and Methods: Twenty-four patients with acute myeloid leukemia (AML), sixteen patients with acute lymphoblastic leukemia (ALL) and fifteen control subjects were included in the current study. TNFR2 was measured in plasma of all subjects by enzyme-linked immunosorbent assay.

Results: Plasma TNFR2 significantly increased in ALL compared to both control and AML cases.

Conclusions: TNFR2 may be used as a biomarker for differentiating between AML and ALL patients.


Keyword:     Tumor Necrosis Factor Receptor 2 Acute leukemia Myeloid Lymphoblastic.

Citation:

El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, AlGayyar MMH. Tumor Necrosis Factor Receptor 2: Its Clinical Significance and Clinicopathologic Correlation in acute leukemias. J App Pharm Sci, 2015; 5 (11): 079-083.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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