Research Article | Volume: 5, Supplement: 3, November, 2015

Further constituents of Vernonia cineria leaves

Augustine A. Ahmadu Adebola Onanuga   

Open Access   

Published:  Nov 12, 2015

DOI: 10.7324/JAPS.2015.510.S12

The genus Vernonia consists of over 1000 species and members of the genus are widely used as food and medicine. As part of our continuing research into ethnomedicinal plant of Nigeria for bioactive plant metabolites, the leaves of Vernonia cineria was investigated for phytochemical constituents. The pulverized leaves of Vernonia cineria were extracted with 70% ethanol and the crude ethanolic extract was suspended in water and partitioned with n-hexane, ethyl acetate and n-butanol. The n-hexane and ethyl acetate soluble parts which showed similar spots on thin layer chromatography were pooled together and coded V1. Extensive column chromatography of V1 afforded the triterpenoids: Lupenol and Oleanan-12.15 dein-28-oic acid. The structures were elucidated using NMR an MS and compared with literature. The oily fraction was subjected to GC-MS equipped with library data to give fatty acids and long chain hydrocarbons. Antibacterial investigation of the ethanol extract at concentration in the range 5-50 mg/ml against the clinical isolates of S. aureus, B. subtilis, E. coli and P. aeruginosa did not show any activity.

Keyword:     Vernonia cineria triterpenoids fatty acids.


Augustine A. Ahmadu and Adebola Onanuga. Further constituents of Vernonia cineria leaves. J App Pharm Sci, 2015; 5 (Suppl 3): 070-073.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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