Research Article | Volume: 5, Supplement: 3, November, 2015

Antioxidant, Antimicrobial and Antidiarrhoeal Activity of Methanolic Extract of Rumex maritimus L. (Polygonaceae)

Md. Shafayat Hossain A. H. M. Arifur Rashid Md. Mahmudur Rahman Samir Kumar Sadhu   

Open Access   

Published:  Nov 12, 2015

DOI: 10.7324/JAPS.2015.510.S10
Abstract

The aim of this current study was to evaluate phytochemistry along with pharmacological activities of the whole plant of Rumex maritimus L. (Family: Polygonaceae). Phytochemical analysis of the extract of R. maritimus indicates the presence of Reducing Sugar, Glycoside, Gum, Tannin and Alkaloid type compounds and the pharmacological attention of these compounds prompted us to check R. maritimus for possible anti-oxidant, antimicrobial and antidiarrheal activities in a dose dependent manner. The dried plants were subjected to successive extraction with methanol and the extract was used to investigate the activities. The extract of plants produced good diarrheal inhibition in castor oil induced diarrhea in mice (250mg/kg and 500mg/kg body weight) which was comparable to the standard drug Loperamide at the dose of 3 mg/kg of body weight. The alcoholic extract was showed anti-bacterial activity against the tested microorganisms (both gram positive as well as negative bacteria). This study reveals the potent anti-oxidant activity that is (IC50~80 µg/ml) to that of standard drug ascorbic acid (IC50 about ~7 µg/ml) in-vitro when tested in 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging method. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.


Keyword:     R. maritimus Polygonaceae anti-oxidant DPPH scavenging antimicrobial and antidiarrhoeal activities.


Citation:

Md. Shafayat Hossain, A. H. M. Arifur Rashid, Md. Mahmudur Rahman, Dr. Samir Kumar Sadhu. Antioxidant, Antimicrobial and Antidiarrhoeal Activity of Methanolic Extract of Rumex maritimus L. (Polygonaceae). J App Pharm Sci, 2015; 5 (Suppl 3): 056-060.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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