Research Article | Volume: 5, Supplement: 3, November, 2015

Synthesis and Characterization of Novel Hydrazone Based Anti-mutagenic and Antioxidative Agents

Emrah Giziroglua Cengiz Sarikurkcub Nurdan Saracc   

Open Access   

Published:  Nov 12, 2015

DOI: 10.7324/JAPS.2015.510.S9

The present study was designed to produce novel hydrazine and evaluate their biological properties including antioxidant, antityrosinase and antimutagenic. 4-allyloxybenzoyl hydrazine (1) reacts with 5-acetyl-1,3-dimethyl barbituric acid (2) and 2-Isonitrosoacetophenone (3) in the presence of acetic acid as a catalyst to produce the hydrazone derivatives 4 and 5 in high yields respectively. The new hydrazone derivatives 4 and 5 have been fully characterized by using multinuclear NMR (1H, 13C) spectroscopy and elemental analysis. The compounds 4 and 5 were studied for their antioxidant and tyrosinase enzyme inhibition activity. In addition the mutagenic and antimutagenic activities were evaluated by Ames Salmonella/ microsome mutagenicity test. The results showed that both of compounds exhibited significant antioxidative and antimutagenic activity and compound 5 has shown moderate tyrosinase inhibition activity. This study suggested that these compounds could be considered as novel bioactive agents in pharmaceutical area.

Keyword:     Hydrazone Oxime Anti-mutagen Antioxidant.


Giziroglu E., Sarikurkcu C., Sarac N. Synthesis and Characterization of Novel Hydrazone Based Anti-mutagenic and Antioxidative Agents. J App Pharm Sci, 2015; 5 (Suppl 3): 048- 055.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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