Research Article | Volume: 5, Issue: 9, September, 2015

Spectral, Magnetic and Biological Studies of ZnII Complexes of Schiff Bases Derived From 4-(O-Methoxyphenyl)-2-Aminothiazole

Netaji N. Karale Rajendra H. Patil   

Open Access   

Published:  Sep 27, 2015

DOI: 10.7324/JAPS.2015.50908
Abstract

In the present ZnII complexes of Schiff bases (SB-1 to SB-7) derived form 4-(o-methoxyphenyl)-2-aminothiazole and R substituted salicylaldehyde (R = H, 3-Me, 4-Me, 5-Me, 3-OMe and 5-Br) and 2-hydroxy-1-naphthaldehyde o-hydroxyaldehydes were synthesized, characterized and tested for the bioactivity against Gram positive and Gram negative group of organisms. The as-synthesized complexes were characterized by elemental, spectral and spectroscopic methods for measuring magnetic susceptibility, conductivity and assayed for biological activities. The complexes showed 1:2 metal : ligand stoichiometry (ML2) and an octahedral geometry. The complexes showed an antibacterial activity against Bacillus subtilis 2063 and Escherichia coli 2931, and antifungal activity by preventing the dimorphic switching in Candida albicans.


Keyword:     ZnII complexes Schiff base dimorphic switching antibacterial activity.


Citation:

Netaji N. Karale Rajendra H. Patil. Spectral, Magnetic and Biological Studies of Znii Complexes of Schiff Bases Derived Form 4-(O-Methoxyphenyl)-2-Aminothiazole. J App Pharm Sci, 2015; 5 (09): 041-044.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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