Research Article | Volume: 5, Supplement: 2, September, 2015

Gastroprotective Role of the Combined Effects of Vitamins C and E Following Chronic Exposure to Thermoxidized palm oil in Albino Rats

Agona Odeh Obembe Emmanuel Oleba Ofutet Atim Irene Okpo-Ene Enobong Samuel Udondian   

Open Access   

Published:  Sep 04, 2015

DOI: 10.7324/JAPS.2015.58.S12

The effect of vitamins C and E on gastric acid secretion and cytoprotection on rats fed with thermally oxidized palm oil (TPO) was studied. Forty five albino wistar rats weighing 180 – 210g were randomly assigned into 3 groups (n = 15). Group 1 served as control and received normal rat feed. Groups 2 and 3 were fed with TPO diet. TPO diet was formulated by mixing rat feed with TPO in the ratio of 85g:15g. Group 3 rats received vitamins C (10mg/100g body weight) & E (400IU/100g body weight) in addition. The drugs were administered orally. All animals had access to water ad libitum. The feeding lasted for 28 days, after which gastric acid output, gastric mucus output and ulcer scores were assessed, using standard methods. Results showed that animals in the TPO group had significant increase in gastric acid secretion (p< 0.05), decrease in mucus output (p

Keyword:     Cytoprotectionpalm oilthermoxidized palm oilvitamin Cvitamin E.


Agona Odeh Obembe, Emmanuel Oleba Ofutet, Atim Irene OkpoEne, Enobong Samuel Udondian. Gastroprotective Role of the Combined Effects of Vitamins C And E Following Chronic Exposure TO Thermoxidized palm oil in Albino Rats. J App Pharm Sci, 2015; 5 (Suppl 2): 076-080.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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