Research Article | Volume: 5, Issue: 8, August, 2015

Hepatotoxicity following separate administration of two phosphodiesterase-5 inhibitors (sildenafil & tadalafil) and opioid (tramadol); evaluation of possible reversal following their withdrawal

Victor U. Nna Ubom P. Akpan Victoria E. Okon Item J. Atangwho   

Open Access   

Published:  Aug 28, 2015

DOI: 10.7324/JAPS.2015.50817
Abstract

The use of phosphodiesterase-5 inhibitors (PDE5i) and tramadol in the absence of erectile and ejaculatory dysfunctions in Nigeria has become a norm. In this study, we comparatively assess the effects of chronic use of these drugs on hepatotoxicity. Fifty male albino wistar rats weighing 180–200g were randomly assigned into 5 groups (n=10) as follows; control, sildenafil (1mg/100g b.w), tadalafil (1mg/100g b.w), tramadol (2mg/100g b.w) and sildenafil+tramadol treated group (1mg/100g and 2mg/100g b.w, respectively). Drugs were orally administered, once, every two days for 8weeks, at the end of which five animals were sacrificed per group (batch 1), while the remaining five animals per group were allowed for another 8weeks without drug administration (batch 2). Serum concentration of liver enzymes (AST, ALT and ALP) and bilirubin were assessed in both batches. Serum concentrations of AST, ALT, ALP, total bilirubin and unconjugated bilirubin were significantly (p<0.001) increased in all treated groups (batch 1), while conjugated bilirubin concentration was significantly (p<0.001) reduced in all treated groups, compared with control. Serum concentrations of AST and ALT were significantly reduced in sildenafil (p<0.01), tadalafil (p<0.05), tramadol (p<0.001) and sildenafil+tramadol (p<0.001) recovery groups, compared with their treated groups. Total and unconjugated bilirubin fractions were significantly (p<0.05 and p<0.01, respectively) reduced in tadalafil recovery group, compared with the treated group. Sildenafil+tramadol recovery group showed significantly (p<0.001) reduced total and unconjugated bilirubin concentrations, compared with the treated group. Chronic administration of PDE5i and tramadol reversibly altered liver functions.


Keyword:     Hepatotoxicity liver phosphodiesterase-5 inhibitors sildenafil tadalafil tramadol.


Citation:

Victor U. Nna, Ubom P. Akpan, Victoria E. Okon, Item J. Atangwho. Hepatotoxicity following separate administration of two phosphodiesterase-5 inhibitors (sildenafil & tadalafil) and opioid (tramadol); evaluation of possible reversal following their withdrawal. J App Pharm Sci, 2015; 5 (08): 105-113.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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