Research Article | Volume: 5, Issue: 8, August, 2015

Pharmacokinetics of Chloroquine and Metronidazole in Rats

Kudirat Bola Mustapha Moji T Bakare-Odunola Garba Magaji Obiageri O. Obodozie-Ofoegbu David D Akumka   

Open Access   

Published:  Aug 28, 2015

DOI: 10.7324/JAPS.2015.50814
Abstract

The single oral dose pharmacokinetics of chloroquine (5mg/kg body weight) and metronidazole (7.5mg/kg body weight) were studied in rats’ serum. Chloroquine and metronidazole concentrations were measured using high-performance liquid chromatography (HPLC) method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental programme. The Maximum serum concentration Cmax (µg/ml) of chloroquine was 5.70 ± 1.41 while that of metronidazole was 3.13  0.30, Time to peak concentration tmax was 1.00  0.00 (h) and that of metronidazole was 0.83 ± 0.27, Volume of distribution Vd (L) 1.33 ± 0.26 for metronidazole 2.39  0.28; Elimination half-life t1/2 (h) 10.05 ± 3.01 for metronidazole 4.05  0.46. The values were comparable with the works of other authors. Compounds that show very high activity in -vitro may not have in vivo activity, or may be highly toxic using in- vivo models due to undesirable pharmacokinetic properties, and toxicity may result from formation of reactive metabolites. This study assures the quality of the brands of the drugs and encouraged the use of animal model in determining pharmacokinetic properties especially in drug design.


Keyword:     Pharmacokinetic Chloroquine Metronidazole HPLC.


Citation:

Kudirat Bola Mustapha, Moji T Bakara-Odunola, Garba Magaji, Obiageri O. Obodozie-Ofoegbu, David D Akumka., Pharmacokinetics of Chloroquine and Metronidazole in Rats. J App Pharm Sci, 2015; 5 (08): 090-094.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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