Research Article | Volume: 5, Issue: 8, August, 2015

Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome

Chandra Kala Syed Salman Ali Mohd. Abid U S Sharma Najam Ali Khan   

Open Access   

Published:  Aug 28, 2015

DOI: 10.7324/JAPS.2015.50808
Abstract

Objective: To evaluate anti-arthritic potential of methanolic extract of rhizome of Costus speciosus Koen. Methods: The powdered drug was extracted with 80% methanol. The crude extract was subjected to phytochemical investigation and was evaluated for its anti-arthritic potential by freund’s complete adjuvant induced arthritis model in adult wistar albino rats. Determination of different parameters like arthritic score, arthritic index, paw thickness, body weight, and pain, altered liver enzymes and biochemical estimation like, nitric oxide level and Plasma TNF-α level was done. Finally, radiological estimation and histopathology of tibio tarsal joints was performed. Statistical analysis was performed using one way ANOVA followed by Dunnet’s test at different p-values. Results: Phytochemical study revealed the presence of flavonoids, phenolic compound, saponins and carbohydrates. For different parameter mentioned above, anti-arthritic activity shown by prophylactic high dose test extract (200 mg/kg) was as potent as standard drug Indomethacin (10 mg/kg). The effect of Prophylactic low dose extract (100 mg/kg) and therapeutic high dose extract (200 mg/kg) was less than that of Indomethacin (10 mg/kg). Furthermore, Therapeutic low dose extract (100 mg/kg) was not effective. Conclusions: The obtained results indicate that Costus speciosus rhizome extract possess significant anti-arthrtic potential.


Keyword:     Costus speciosus Freund’s complete adjuvant Rheumatoid arthritis biochemical estimation radiological examination.


Citation:

Chandra Kala, Syed Salman Ali, Mohd Abid, Uma Shanker Sharma, Najam Ali Khan. Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome. J App Pharm Sci, 2015; 5 (08): 046-053.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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