Research Article | Volume: 5, Issue: 7, July, 2015
Research Article | Volume: 5, Issue: 7, July, 2015
Developing a new agent in the anti-inflammatory and analgesic field, plants secondary metabolites can be a good source for the Non-Steroidal Anti-inflammatory Drugs (NSAID) drug development. For this purpose we subjected the active compounds of Mimosa pudica Linn. to reveal its potentiality by molecular docking analysis to find out its potent compound against COX which was done by GOLD docking analysis. Docking studies by GOLD showed that vitexin of Mimosa pudica had the highest fitness score against the COX-1 which is 60.43 and 63.49 for COX-2 enzyme. Vitexin of Mimosa pudica detected with significant fitness score and hydrogen bonding against COX-1 and COX-2 which may be a potent analgesic compound.
Ashekul Islam, Mohammad Shah Hafez Kabir, Raju Dash, Talha Bin Emran, Md. Zia Uddin, Khairun Nesa, Mir Muhammad Nasir Uddin and Md. Tanveer Ahsan. Virtual screening for potential COX-inhibiting constituents from Mimosa pudica. J App Pharm Sci, 2015; 5 (07): 071-075.
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