Research Article | Volume: 5, Issue: 7, July, 2015

Synthesis, Evaluation and in silico studies of 1,8-Naphthyridine derivatives against antimicrobial activity

Sakshi Sachdevaa Sonam Bhatiaa Amit Mittala Manish Sinhab   

Open Access   

Published:  Jul 27, 2015

DOI: 10.7324/JAPS.2015.50709
Abstract

In present studies a series of novel 1,8-Naphthyridine derivatives (3a-3f) have been synthesized using nalidixic acid as a starting material. The structures of the compounds were supported by FT-IR, 1H NMR and Mass spectral data. All the synthesized compounds have been evaluated in vitro for their antibacterial activities against several strains of microbes using agar dilution method. The synthesized compounds had moderate to good antibacterial activity. Molecular docking studies reveal that 1,8-Naphthyridine scaffold shared structural complimentary with DNA Gyrase B. Further, TOPKAT analysis on Ames mutagenicity model had shown that this class of compounds have least probability of showing toxicity on experimental animal models.


Keyword:     18-Naphthyridine Nalidixic acid Antimicrobial activity Ames mutagenicity Molecular docking QSTR Structure based design.


Citation:

Sakshi Sachdeva, Sonam Bhatia, Amit Mittal and Manish Sinha. Synthesis, Evaluation and in silico studies of 1,8-Naphthyridine derivatives against antimicrobial activity. J App Pharm Sci, 2015; 5 (07): 053-059.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
389 Views 51 Downloads 440 Total

Year

Month

Related Search

By author names