Research Article | Volume: 5, Issue: 6, June, 2015

Drug-like properties of potential anti-cancer compounds from Cameroonian flora: A virtual studies

Ibezim Akachukwu Onyia Kelechi Ntie-Kang Fidele Nwodo Ngozi Justina   

Open Access   

Published:  Jun 27, 2015

DOI: 10.7324/JAPS.2015.50622
Abstract

Assessment of the ‘drug-like’ using a set of calculated molecular descriptors, of a collection of 195compounds from plants in Cameroon exhibiting in vitro or/and in vivo activities against various cancer cell lines was made. Lipinski’s ‘Rule of Five’ (Ro5) was used to evaluate drug-likeness/oral availability of the compounds by making use of popular parameters like Molecular Weight (MW), predicted lipophilicity (log P), number of Hydrogen Bond Donors/Acceptors (HBD and HBA) and Number of Rotatable Bonds (NRB). The drug-like properties of the studied compounds were compared to that of the Dictionary of Natural Products (DNP). Our results revealed that79.50%, 43.60% and 12.30% of our dataset fall within the recommended range for ‘drug-like’, ‘lead-like’ and ‘fragment-like’ respectively with significant enhancement of some oral availability parameters over DNP and this paints the significant of our dataset in search for lead-like anti-cancer molecules with desirable ‘drug-like’ properties.


Keyword:     Cancer Natural products Drug-likeness Physico-chemical properties.


Citation:

Ibezim, Akachukwu, Onyia, Kelechi, Ntie-Kang, Fidele,Nwodo, Ngozi Justina. Drug-like properties of potential anti-cancer compounds from Cameroonian flora: A virtual studies. J App Pharm Sci, 2015; 5 (06): 133-137.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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