Research Article | Volume : 1 Issue : 6, August 2011

Rapid analytical procedure for Citicoline in bulk and pharmaceutical dosage form by UV Spectrophotometer

Neetu Sachan Phool Chandra Mayank Yadav Dilipkumar Pal Ashoke K Ghosh   

Open Access   


A simple, rapid, accurate, precise, and inexpensive method for the determination of citicoline has been developed using double beam UV spectrophotometer. Ultraviolet spectrophotometric analysis was carried out on a Shimadzu UV 1800 (Shimadzu, Japan) spectrophotometer, in a 1cm quartz cuvette. Citicoline has absorption maxima at 272 nm and the measurements were obtained against distilled water. Beer Lambert’s law was obeyed in the concentration range of 5-50µg/ml with correlation coefficient (r2) 0.9998. The analytical method was successfully validated in order to verify its proper selectivity, linearity, accuracy and precision for the goal intended and its further implementation for the quantification of the active compound in the pharmaceutical speciality for quality control.

Keyword:     Citicoline UV Spectrophotometer Calibration curve.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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