Research Article | Volume: 5, Issue: 5, May, 2015

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

Mohamad Norisham Mohamad Rosdi Nik Nurul Najihah Nik Mat Daud Razauden Mohamed Zulkifli Harisun Yaakob   

Open Access   

Published:  May 27, 2015

DOI: 10.7324/JAPS.2015.50508

Annona muricata Linn has been reported to contain valuable bioactive compounds known as Annonaceous acetogenins. These long chain fatty acids were widely discussed for its potential in promoting anticancer and anti-proliferative activity in various cancer cell lines. However, little study has been done on A. muricata effect in pancreatic cancer cells. In this study, the viability of Capan-1 after treatment with A. muricata extracts was determined by using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results displayed that only hexane and commercialized extract inhibited cell proliferation in a concentration-dependent manner with IC25 varied ~7.8-8μg/ml and ~0.9-1.0μg/ml respectively. The data demonstrate that A. muricata hexane and commercialized extracts induced mild cytotoxicity in pancreatic cancer cells (Capan-1).

Keyword:     Annona muricata LinnGraviolaMTTPancreatic cancerCapan-1Maceration.


Mohamad Norisham Mohamad Rosdi, Nik Nurul Najihah Nik Mat Daud, Razauden Mohamed Zulkifli, Harisun Ya'akob. Annona muricata Linn leaves extract cytotoxicity effect on Capan-1 cells. J App Pharm Sci, 2015; 5 (05): 045-048

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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