Research Article | Volume: 5, Issue: 5, May, 2015

Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application

Mohamed Salama Mahmoud A. Mahdy Amina Mohamed Aref T. Mohamed Eseldin I. Keleb Assad A. Omar Nagib A. Elmarzugi   

Open Access   

Published:  May 27, 2015

DOI: 10.7324/JAPS.2015.50505
Abstract

The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physico-mechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis.


Keyword:     Ketoconazole Eudragit RL 100 Polymeric film Antifungal drugs.


Citation:

Mohamed Salama, Mahmoud A. Mahdy, Amina Mohamed, Aref T. Mohamed, Eseldin I. Keleb, Assad A. Omar, Nagib A. Elmarzugi., Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application. J App Pharm Sci, 2015; 5 (05): 028-032.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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