Research Article | Volume: 5, Issue: 5, May, 2015

Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

Santosh D. Deosarkar Rajendrakumar T. Sawale Tukaram M. Kalyankar   

Open Access   

Published:  May 27, 2015

DOI: 10.7324/JAPS.2015.50503
Abstract

In view of pharmaceutical applications, the density (ρ) and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (φv) were calculated from density data and fitted to the Masson relation to determine partial molar volume (φ°v) of drug. Overall, strong drug-solvent interactions with significant structural changes in pure and mixed solvents have been confirmed.


Keyword:     DensityRefractive indexDrugPartial molar volume.


Citation:

Santosh D. Deosarkar, Rajendrakumar T. Sawale, Tukaram M. Kalyankar. Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in AqueousDimethylsulfoxide (DMSO) Solutions At 303.15 K. J App Pharm Sci, 2015; 5 (05): 013-017.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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