Research Article | Volume: 5, Supplement: 1, May, 2015

Acute Toxicity Studies and Evaluation of Analgesic Property of the Methanol Stem Bark Extract of Neocarya macrophylla

A.J. Yusuf M.I. Abdullahi A.K. Haruna A.M. Musa Z.Y.Y. Ibrahim A. Uba   

Open Access   

Published:  May 15, 2015

DOI: 10.7324/JAPS.2015.54.S10
Abstract

The methanol stem bark extract of Neocarya macrophylla was screened for its analgesic activity using acetic acid-induced writhing in mice and formalin-induced pain in rats. The results of the study showed that the extract (60mg/kg, i.p.) decreased writhing response with 63.9% inhibition. The methanol extract also exhibited significant analgesic effect (P<0.05) in the formalin test which is in the same order of magnitude as that observed after administration of pentazocine (10mg/kg, i.p.) the standard drug. The intraperitoneal median lethal dose (LD50) of the methanol extract of N. macrophylla was found to be 283mg/kg in mice suggesting the plant is fairly toxic. The results of the study have shown that the methanol extract of N. macrophylla possesses analgesic activity which rationalizes the traditional use of the plant in the management of pain.


Keyword:     Neocarya macrophyllaextractformalinacetic acid and analgesic models.


Citation:

Yusuf A. J., Abdullahi M. I.. Haruna A. K.,Musa A. M, Ibrahim Z. Y. Y., Uba A. Acute Toxicity Studies and Evaluation of Analgesic Property of the Methanol Stem Bark Extract of Neocarya Macrophylla. J App Pharm Sci, 2015; 5 (Suppl 1): 061-064.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
395 Views 17 Downloads 412 Total

Year

Month

Related Search

By author names