Research Article | Volume: 5, Issue: 3, March, 2015

Antimicrobial and cytotoxic acetogenin from Polyalthia debilis

Somchai Boonpangrak Rungrot Cherdtrakulkiat Ratchanok Pingaew Patumporn Manam Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul   

Open Access   

Published:  Mar 28, 2015

DOI: 10.7324/JAPS.2015.50303
Abstract

The objective of the study was to isolate bioactive acetogenin compound and to investigate antimicrobial, antioxidant as well as cytotoxic activities of the isolate, fractions and extracts of Polyalthia debilis. The P. debilis (roots) extracts and isolated compound were tested for their antimicrobial (agar dilution method) against twenty-seven strains of microorganisms (gram positive and gram negative bacteria, and diploid fungus), antioxidant (DPPH assay) and cytotoxic activities. The plant extracts were isolated by column chromatography and structure of compound was confirmed by spectral data. The plant extracts and isolated fractions exhibited antioxidant and cytotoxic activities. The isolated acetogenin 1 (debilisone E) displayed antimicrobial activity against Morexella catarrhalis with the MIC of 64 µg/mL, Corynebacterium diphtheriae NCTC 10356 and Streptococcus pyogenes with partial inhibition (50-75%) at 128 µg/mL. The compound 1 exerted cytotoxic activity against 5 cancer cells (HepG2, A549, HCC-S102,HL-60 and P388) with IC50 values 18.4 - 40.3µg/mL. The results demonstrate novel bioactivities of P. debilis as antimicrobials and anticancer agents.


Keyword:     Polyalthia debilis Annonaceae Bioactive acetogenin Antimicrobials Antioxidants Cytotoxic agents.


Citation:

Somchai Boonpangrak, Rungrot Cherdtrakulkiat, Ratchanok Pingaew, Patumporn Manum, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul. Antimicrobial and cytotoxic acetogenin from Polyalthia debilis. J App Pharm Sci, 2015; 5 (03): 013-018.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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