Research Article | Volume: 4, Issue: 12, December, 2014

Comparative Evaluation of the Disintegrant Properties of Rice Husk Cellulose, Corn Starch and Avicel in Metronidazole Tablet Formulation

Onyinye Jennifer Uwaezuoke Oluyemisi A. Bamiro Ndidi C. Ngwuluka Omolola Tolulope Ajalla Aderonke O. Okinbaloye   

Open Access   

Published:  Dec 29, 2014

DOI: 10.7324/JAPS.2014.41219
Abstract

Cellulose is a polysaccharide that has been employed in pharmaceutical applications over the years. However, the quest for waste management and an alternative to imported raw materials for locally manufactured drug products necessitated this study. This study was undertaken to explore the application of cellulose extracted from waste, rice husk as a disintegrant in the formulation of metronidazole tablets for immediate release. Cellulose was extracted from rice husk and characterized. Thereafter, a comparative characterization of the attributes of the tablets formulated was undertaken using Corn Starch, microcrystalline cellulose and rice husk as disintegrants. The granules were characterized for flow properties and tablets were evaluated for crushing strength, friability, disintegration and in vitro drug release. The tablets formulated with rice husk cellulose were found to be bioequivalent to those of corn starch which is a standard in comparative studies of disintegrants. Hence, rice husk cellulose is an alternative excipient to explore as a pharmaceutical excipient for limited resource economies.


Keyword:     Rice husk cellulose disintegrant immediate release tablets metronidazole polysaccharide polymer.


Citation:

Onyinye Jennifer Uwaezuoke, Oluyemisi A Bamiro, Ndidi C Ngwuluka, Omolola Tolulope Ajalla, Aderonke O Okinbaloye. Comparative Evaluation of the Disintegrant Properties of Rice Husk Cellulose, Corn Starch and Avicel in Metronidazole Tablet Formulation. J App Pharm Sci, 2014; 4 (12): 112-117.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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