Research Article | Volume: 4, Issue: 12, December, 2014

The possible protective effect of Coriandrum sativum seeds methanolic extract on hepato-renal toxicity induced by sodium arsenite in albino rats

Mostafa Saeed,  Ahmed Amen,  Abdelgawad Fahmi,  Islam El Garawani,  Sadya Sayed   
Mostafa Saeed1, Ahmed Amen2, Abdelgawad Fahmi2, Islam El Garawani3, Sadya Sayed1

1Biochemistry Dep., National Organization for Drug Control and Research (NODCAR), Egypt.

2Biochemistry Dep., Fac. of Science, Cairo University, Egypt.

3Molecular Biology Dep., Fac. of Science, Menoufya University, Egypt.

Open Access   

Published:  Dec 29, 2014

DOI: 10.7324/JAPS.2014.41208
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Abstract

This work has been carried out in order to investigate the possible ameliorative effect of Coriander seeds methanolic extract (CSE) on sodium arsenite (As) – induced toxicity in albino rats. 2,3 Dimercaptosuccinic acid (DMSA) was used as a standerd chelating agent. The experiment lasted for 8 weeks and blood samples were withdrawn 4 and 8 weeks after As and other treatments administrations. As was used to induce hepatotoxicity in rats in a dose equivalent to 100 p.p.m . In-vivo studies using the different biochemical techniques employed in hepato-renal functions as well as liver apoptotic DNA and total RNA alterations proved that As caused a significant increase in parameters concerned to hepato-renal toxicity while treatment of CSE or DMSA caused an ameliorative effect on this toxicity. Administration of CSE and DMSA together along with arsenite proves the synergistic effects of these chelating agents on arsenite toxicity.


Keyword:     Coriandrum sativum Sodium arsenite Hepato-renal functions RNA and DNA fragmentation Apoptosis.

Citation:

Mostafa Saeed, Ahmed Amen, Abdelgawad Fahmi, Islam El Garawani, Sadya Sayed. The possible protective effect of Coriandrum sativum seeds methanolic extract on hepato-renal toxicity induced by sodium arsenite in albino rats. J App Pharm Sci, 2014; 4 (12): 044-051.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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