Research Article | Volume: 4; Issue: 11, November, 2014
Research Article | Volume: 4; Issue: 11, November, 2014
Olanzapine, an antipsychotic agent, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Olanzapine by preparing microspheres by spray drying technique using β-cyclodextrin. Olanzapine Microspheres containing different ratios of β-cyclodextrin were produced by spray drying using Propanol and water (50:50) as solvent system to enhance solubility and dissolution rate. The prepared formulations containing different ratios of drug and β-cyclodextrin were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared spray dried microspheres was compared with its physical mixture and pure sample. Spray dried microspheres exhibited decreased crystallinity. The solubility of microspheres containing Olanzapine and β-cyclodextrin (1:3w/w) exhibited tenfold increases than the commercial Olanzapine and dissolution of same ratio microsphere showed 99 % release in 20 min. while same composition in physical mixture showed 37% release in 20 min. Consequently, from the above result it can be concluded that spray dried microspheres of Olanzapine is a useful technique to improve the solubility and dissolution of poor water soluble drug like Olanzapine.
Mudit Dixit, R. Narayana Charyulu. Anupama Shetty, Narayana Charyalu, Meghana Rao, Pallavi Bengre, Sharin Thomas. Enhancing Solubility and Dissolution of Olanzapine by Spray Drying Using β- Cyclodextrin Polymer. J App Pharm Sci, 2014; 4 (11): 081-086.
Year
Month
Physicochemical characterization of spray dried cefixime polymeric nanoparticles using factorial design approach
Formulation and evaluation of Salbutamol sulphate microspheres by solvent evaporation method
V.V Prasanth, Akashmoy Chakraborty, Sam T Mathew, Rinku Mathappan, V. KamalakkannanAn evaluation of the metabolic effects of antipsychotic medications in patients suffering from psychiatric illness
Enhancement of Oral Bioavailability and Solid Dispersion: A Review
Nadia Saffoon, Riaz Uddin, Naz Hasan Huda, Kumar Bishwajit SutradharProcess optimization of efavirenz film coated tablet
K. Bala Krishna, M. Saritha