Research Article | Volume: 4, Issue: 10, October, 2014

Gastro-protective, Anti-Helicobacter pylori and, Antioxidant Properties of Moroccan Zizyphus lotus L.

Fatima-Zahra Bakhtaoui Hind Lakmichi Francis Megraud Abderrahmane ChaitChems-Eddoha A. Gadhi   

Open Access   

Published:  Oct 30, 2014

DOI: 10.7324/JAPS.2014.401015

Zizyphus lotus L. is a common medicinal plant used in Moroccan folk medicine to treat gastrointestinal disorders such as ulcers and diarrhea. In this paper, we aimed to evaluate the anti-ulcer properties of Z. lotus (fruits) methanol extract (ZLM) in various experimental models, as well as its anti-Helicobacter pylori and anti-scavenging properties. Anti-ulcer studies were performed in three ulcerogenic induced models (HCl/Ethanol; HCl/EtOH), pylorus ligature and aspirin) in Wistar rats. Up to 500 mg/kg body weight, ZLM produced a non-significant inhibition in the acute ulcer induced by HCl/EtOH solution and a significant effect on the aspirin model (46.2 %). The anti-ulcer effect was lower, for both models, compared to cimetidine and omeprazole used as positive controls. ZLM showed a significant reduction of gastric juice secretion and total acidity and an increase in pH value in pylorus-ligature model similarly to positive controls. ZLM inhibited, at 128µg/ml, three H. pylori clinical strains among which two were resistant to metronidazole and clarythromycine. ZLM showed a moderate scavenging capacity in DPPH assay (IC50= 477.6 ± 47.6 µg/ml). ZLM extract act essentially as antacid agent, which support the use of this plant in the traditional Moroccan medicine to cure gastrointestinal disorders.

Keyword:     Moroccan folk medicine Zizyphus lotus (L.) antioxidant potential gastric ulcer Helicobacter pylori.


Fatima-Zahra Bakhtaoui, Hind Lakmichi, Francis Megraud, Abderrahmane Chait, Chems-Eddoha A. Gadhi. Gastro-protective, Anti-Helicobacter pylori and, Antioxidant Properties of Moroccan Zizyphus lotus L. J App Pharm Sci, 2014; 4 (10): 081-087.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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