Research Article | Volume: 4; Issue: 9, September, 2014

Anti-amnesic effect of aqueous extract of Crataeva nurvala stem bark in scopolamine induced amnesia

Anshul Tanwar Pallavi A Bafna Anand R Bafna   

Open Access   

Published:  Sep 27, 2014

DOI: 10.7324/JAPS.2014.40912
Abstract

Aim of the study was to evaluate the anti-amnesic effects of Crataeva nurvala stem bark in scopolamine induced amnesia in rats. The standardized aqueous extract of Crataeva nurvala (AECN) was freshly dissolved in distilled water and administered orally to rats at the dose of 500 mg/kg for evaluation of its effects against scopolamine (3 mg/kg, i.p.) induced retrograde and anterograde amnesia. The effects of the extract on escape latency during the acquisition trial (Days 1-4) and the time spent in target quadrant (TSTQ) during the retrieval trial (Day 5) were determined using the Morris water maze test. In order to indicate the probable mechanism of C. nurvala, its effects on acetylcholinesterase (AchE) and TBARS levels in the brain were determined. In scopolamine induced retrograde amnesia treatment with AECN showed a significant (p<0.05) increase in TSTQ and reduction (p<0.001) in levels of both AchE and TBARS in brain. In the anterograde amnesia model AECN significantly (p<0.001) reduced the escape latency and increased (p<0.01) the TSTQ. The extract also lowered the levels of AchE (p<0.01) and TBARS (p<0.001) in the brain of scopolamine induced anterograde amnesic rats.The study proved that AECN possesses positive effects on memory and learning, which may be due to decrease in AchE levels and inhibition of lipid peroxidation in the brain.


Keyword:     Alzheimer Morris water maze acetylcholinesterase lipid peroxidation.


Citation:

Anshul Tanwar, Pallavi A Bafna, Anand R Bafna. Anti-amnesic effect of aqueous extract of Crataeva nurvala stem bark in scopolamine induced amnesia. J App Pharm Sci, 2014; 4 (09): 066- 072.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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