Research Article | Volume: 4, Issue: 7, July, 2014

Assessment of cytotoxic activities of Phyllanthus amarus and Monstera deliciosa

Dilshad Noor Lira Md. Aftab Uddin Mohi Uddin Abu Shara Shamsur Rouf   

Open Access   

Published:  Jul 28, 2014

DOI: 10.7324/JAPS.2014.40719

Medicinal plants constitute an important component of flora and are widely distributed in Bangladesh. The pharmacological evaluation of substances from plants is an established method for the identification of lead compounds which shows the way to the development of novel and safe medicinal agents. Based on the ethnopharmacological literature two widely used medicinal plants Phyllanthus amarus and Monstera deliciosa were chosen to investigate their cytotoxicity through brine shrimp lethality bioassay which is simple, reliable and convenient method for assessment of bioactivity of medicinal plants. The plants were collected from their natural habitat, dried under shade and extracted with ethyl acetate. In this study, ethyl acetate extract of Phyllanthus amarus exhibited potent cytotoxicity with LC50 values of 9.15 µg/ml and 20.16 µg/ml of leaves and the whole plant respectively. Monstera deliciosa exhibited cytotoxicity with LC50 values of 36.60µg/ml and 300.4 µg/ml of leaves and branches respectively. From the result, it can be predicted that extractives of Phyllanthus amarus possess cytotoxic principles and showed significantly more potency than in leaves rather than whole plant. In case of Monstera deliciosa the extractives of leaves exhibited very mild mortality while the extractives of branches did not show considerable cytotoxicity.

Keyword:     Phyllanthus amarus Monstera deliciosa Brine shrimp Cytotoxicity.


Dilshad Noor Lira, Md. Aftab Uddin, Mohi Uddin, Abu Shara Shamsur Rouf. Assessment of cytotoxic activities of Phyllanthus amarus and Monstera deliciosa. J App Pharm Sci, 2014; 4 (07): 110-113.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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