Research Article | Volume: 4, Issue: 7, July, 2014

Thermal analysis on phase sensitive granisetron in situ forming implants


Open Access   

Published:  Jul 28, 2014

DOI: 10.7324/JAPS.2014.40702

In this study effect of gamma irradiation sterilization and storage conditions on thermal properties of phase sensitive granisetron in situ forming implant (ISFI) was investigated. ISFI was prepared by mixing Poly (DL-lactide-co-glycolide) (PLGA) with dimethylsulfoxide (DMSO) : propylene carbonate (PC) (1:1) solvent combination then granisetron HCl was added and homogenized. Following application of gamma irradiation, ISFI was stored at 25 °C for 4 months. Differential Scanning Calorimeter (DSC) measurements and Thermogravimetric Analysis-Differential Thermal Analysis (TGA-DTA) were carried out on fresh, irradiated and aged forms of granisetron ISFI. According to DSC, TGA and TGA-DTA thermograms and mass loss results application of gamma irradiation and storage of irradiated ISFI at 25 °C for 4 months have not significant effect on thermal stability of ISFI.

Keyword:     In situ forming implant Poly(DL-lactide-co-glycolide) Gamma irradiation sterilization DSC TGA-DTA Stability.


Evren ALGIN YAPAR, Tamer BAYKARA., Thermal Analysis on Phase Sensitive Granisetron In Situ Forming Implants. J App Pharm Sci, 2014; 4 (07): 010-013.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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