Research Article | Volume: 4, Issue: 3, March, 2014

Chemical composition, antifungal and antioxidant activity of Pelargonium graveolens essential oil

Ana M. Dzamic,  Marina D. Sokovic,  Mihailo S. Ristic,  Slavica M. Grujic,  Ksenija S. Mileski,  Petar D. Marin   

Ana M. Dzamic1, Marina D. Sokovic2, Mihailo S. Ristic3, Slavica M. Grujic1, Ksenija S. Mileski1, Petar D. Marin1

1Department of Morphology and Systematics of Plants, Institute of Botany and Botanical Garden "Jevremovac", Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia.

2Department of Plant Physiology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despota Stefana 142, 11000 Belgrade, Serbia.

3Institute for Medicinal Plant Research “Dr Josif Pančić”, Tadeuša KošÄ‡uška 1, 11000 Belgrade, Serbia.

Open Access   

Published:  Feb 27, 2014

DOI: 10.7324/JAPS.2014.40301
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Abstract

The present study describes the chemical composition, antifungal and antioxidant activity of Pelargonium graveolens essential oil. The essential oil profile was determined by GC and GC-MS. The main compounds were citronellol (24.54%), geraniol (15.33%), citronellyl formate (10.66%) and linalool (9.80%). Minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) were recorded using the microdilution and macrodilution methods. Commercial antimycotic bifonazol was used as a control. The concentration of 0.25-2.5 mg/ml showed fungicidal activity. The most resistant fungi were Mucor mucedo and Aspergillus species. The antioxidant activity of pure essential oil was evaluated by means of the 2,2-diphenyl-1-picrylhydrazil (DPPH) radical assay. The essential oil of P. graveolens was able to reduce DPPH radicals into the natural DPPH-H form, and this activity was dose-dependent. The oil exhibited antioxidant activity and reduced DPPH to 50% at EC50 value of 0.802 mg/ml of oil solution.


Keyword:     Pelargonium graveolens essential oil microdilution method macrodilution method DPPH.

Citation:

Dzamic AM, Sokovic MD, Ristic MS, Grujic SM, Mileski KS, Marin PD. Chemical composition, antifungal and antioxidant activity of Pelargonium graveolens essential oil. J App Pharm Sci, 2014; 4 (03): 001-005.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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