Short Communication | Volume: 4, Issue: 1, January, 2014

Melanogenesis Inhibitory Activity in the Extracts of Oreocnide fruticosa (Gaudich.) Hand-Mazz. Branches

Jung Hwan Han Sang-Hee Byeon Chang-Gu Hyun and Nam Ho Lee   

Open Access   

Published:  Jan 30, 2014

DOI: 10.7324/JAPS.2014.40126

Development of anti-melanogenic agents from natural sources has long been the research project of our laboratory. In this study, ethyl acetate extracts of Oreocnide fruticosa (Gaudich.) Hand.-Mazz. branches (OBE) were examined for their melanin synthesis inhibitory activities using B16 melanoma cells. Our results indicated that OBE down-regulates melanin production in a dose-dependent pattern. To clarify the target of OBE action in melanogenesis, we performed Western blotting for the key melanogenic enzymes; tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2. The results showed that OBE efficiently inhibited tyrosinase, TRP-1 and TRP-2 in a dose-dependent manner. Therefore, OBE is a good candidate for the further study including identification of the effective chemical constituents as well as their working mechanism for the application of whitening agent in the human skin.

Keyword:     Oreocnide fruticosa (Gaudich.) Hand.-Mazz. melanin anti-melanogenesis tyrosinase.


Jung Hwan Han, Sang-Hee Byeon, Chang-Gu Hyun and Nam Ho Lee. Melanogenesis Inhibitory Activity in the Extracts of Oreocnide fruticosa (Gaudich.) Hand.-Mazz. Branches. J App Pharm Sci, 2014; 4 (01): 166-169.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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