Research Article | Volume: 4, Issue: 1, January, 2014

Antioxidant properties of Coscinium fenestratum stem extracts on Streptozotocin induced type 1 diabetic rats

Neethu P. Haseena P. ZevaluKezo Sona Thomas R. Santhosh Wilson Goveas and Asha Abraham   

Open Access   

Published:  Jan 30, 2014

DOI: 10.7324/JAPS.2014.40105
Abstract

The aim of this investigation was to study the antioxidant status of Streptozotocin induced diabetic rats which were treated with methanolic stem extract of Coscinium fenestratum. Diabetes was induced by administering STZ by intra femoral vein injection at a dose of 40mg/kg body weight. Methanolic extract of Coscinium fenestratum was administered to the rats at a dose of 200 mg/kg body weight for a period of two weeks. The antioxidant status of the treated animals were assessed by measuring the activity of liver enzymes such as Catalase, Super oxide dismutase and Glutathione S Transferase. Levels of these antioxidant enzymes decreased in untreated diabetes compared to normal values. Administration of methanolic fractions of Coscinium fenestratum in STZ induced diabetic rats reversed these changes. Oxidative stress plays a major role in generation of free radicals in the pathogenesis of diabetes and its complications. Our findings suggest that C. fenestratum methanolic extract exerted anti-hyperglycemic activity by combating the oxidative stress, improving the glycogen content and by activating the carbohydrate metabolizing enzyme Hexokinase. The presence of Berberine and other phenolic compounds in the stem extracts may be responsible for this action.


Keyword:     Coscinium fenestratum Methanolic fraction Anti diabetic Antioxidants Glycogen content Hexokinase.


Citation:

Neethu P., Haseena P., ZevaluKezo, Sona Thomas R., Santhosh Wilson Goveas and Asha Abraham., Antioxidant properties of Coscinium fenestratum stem extracts on Streptozotocin induced type 1 diabetic rats. J App Pharm Sci, 2014; 4 (01): 029-032.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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