Research Article | Volume: 3, Issue: 12, December, 2013

Phytochemical and antimicrobial screening of crude methanolic leaf extract of Peucedanum winkleri H. Wolff.

Madumelu M Ndukwe IG and Ayo RG   

Open Access   

Published:  Dec 30, 2013

DOI: 10.7324/JAPS.2013.31223
Abstract

Phytochemical investigation of the leaves of Peucedanum winkleri H. Wolff, revealed the presence of secondary metabolites. The extract from total extraction with methanol was screened for its antimicrobial activity against Staphylococcus aureus, Methicillin resistant Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pyogenes, Proteus mirabilis, Candida albicans and Candida krusei using agar-well difussion method. The result indicated that the extract inhibited the growth of one or more test pathogens and were compareable with those of the standard drugs used. The minimun inhibitory concentration (MIC) ranges from 5-10 mg/ml and the minimun bactericidal/fungicidal concentration (MBC/MFC) ranges from 20-40 mg/ml. The result of the study shows justification for the use of the plant for the treatment of infectious diseases caused by these bacteria and fungi pathogens. It was concluded that P. winkleri H. Wolff could be a potential source of active antimicrobial agents and a detailed assessment of antimicrobial activity of the plant material in other solvents extract, isolation and characterization of active compounds from the most active extract is on-going.


Keyword:     Phytochemical investigation Peucedanum winkleri minimun inhibitory concentration (MIC) minimun bactericidal/ fungicidal concentration (MBC/MFC).


Citation:

Madumelu M., Ndukwe IG. and Ayo RG. Phytochemical and antimicrobial screening of crude methanolic leaf extract of Peucedanum winkleri H. Wolff. J App Pharm Sci, 2013; 3 (12): 129-132.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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