Research Article | Volume: 3, Issue: 12, December, 2013

Evaluation of wound healing activity of baicalein-7-O- β-D-glucuronide isolated from Leucas aspera

Prabakaran Kalaivanan Ilayaraja Sivagnanam and Manivannan Rajamanickam   

Open Access   

Published:  Dec 30, 2013

DOI: 10.7324/JAPS.2013.31208

Leucas aspera (Willd.) Linn. (Lamiaceae), commonly known as “Thumbai” is distributed throughout India. This study includes the isolation and characterization of flavonoids present in Leucas aspera flowers were compared wound healing activity with standard soframycin ointment. The plant materials were extracted with 95% methanol, petroleum ether, ethyl acetate, and were subjected to column and TLC chromatographic separation analysis. The chemical constituents isolated from the flowers of L. aspera were characterized based on chemical tests and spectral analysis such as UV and NMR spectroscopy. The structure of the isolated compound was confirmed as baicalein-7-O- β-D-glucuronide (baicalin). It has been investigated for wound healing activity by applying on the albino rats. A slow rate of healing was observed earlier which turns to very rapid on the 12th day. The histopathological examination provided additional evidence for the experimental wound healing studies. Protease is a biochemical marker and pH measured to support the wound healing activity. We conclude that the baicalin isolated with the flowers of L. aspera has better wound healing activity.

Keyword:     Baicalein-7-O- β-D-glucuronide Leucas aspera Wound Healing.


Prabakaran Kalaivanan, Ilayaraja Sivagnanam and Manivannan Rajamanickam. Evaluation of wound healing activity of baicalein7-O- β-D-glucuronide isolated from Leucas aspera. J App Pharm Sci, 2013; 3 (12): 046-051.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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