Research Article | Volume: 3, Issue: 11, November, 2013

Synthesis and antimicrobial evaluation of novel 3-(4,6- diphenyl-6H-1,3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives

Sayaji S. Didwagh Pravina B. Piste Aravind S. Burungale Avinash M. Nalawade   

Open Access   

Published:  Nov 29, 2013

DOI: 10.7324/JAPS.2013.31122
Abstract

A novel series of potentially biologically active 3-(4,6-diphenyl-6H-1,3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives (5a-5k) have been synthesized by the condensation-cyclization reaction of 4,6-diphenyl-6H-1,3-thiazin-2-amine, aromatic aldehyde and thioglycolic acid in polypropylene glycol at 1100C temperature. The structure of the newly synthesized compounds has been established on the basis of their spectral data and elemental analysis. The antimicrobial activity of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus, Bacillus subtilis as a Gram positive bacteria and Escherichia coli, Pseudomonas aeruginosa as a Gram negative bacteria and two pathogenic fungal strains Candida albicans, Aspergillus niger by using the disc diffusion method. The detailed synthesis, spectroscopic data, and antimicrobial screening of synthesized compounds were reported.


Keyword:     Synthesis chalcone thiazine thiazolidin-4-one antimicrobial activity.


Citation:

Sayaji S. Didwagh, Pravina B. Piste, Aravind S. Burungale, Avinash M. Nalawade. Synthesis and antimicrobial evaluation of novel 3-(4,6- diphenyl-6H-1,3- thiazin -2-yl)-2- (4- methoxyphenyl) thiazolidin-4-one derivatives. J App Pharm Sci, 2013; 3 (11): 122-127.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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