Research Article | Volume: 3, Issue: 11, November, 2013

Controlled drug release studies of valsartan using differently sulfonated methacryloxyacetophenone and methyl methacrylate co-polymer resins as drug carriers

K. Doraswamy V. Nagaraju R. Srinivasulu and P. Venkata Ramana   

Open Access   

Published:  Nov 29, 2013

DOI: 10.7324/JAPS.2013.31120
Abstract

2-methacryloxyacetophenone (MAP) was prepared and subjected to suspension polymerization with methyl methacrylate (MMA) using benzoylperoxide (BPO) as free radical initiator. The differently sulfonated MAP-MMA cross-linked copolymer cationic exchange resins were prepared by sulfonation with concentrated sulphuric acid at 70oC. Several characteristics of the prepared resins were evaluated, i.e. FT-IR, the Ion-exchange capacity (IEC), Swelling studies, Particle size distribution and Microscopic morphology. The resin characteristics were altered with degree of sulfonation, providing that differently sulfonated resins could be prepared. The behavior of valsartan (VLN) loading and in vitro release in the USP stimulated gastric and intestinal fluids of the obtained resins were evaluated. The drug loaded in the resin increased with increasing degree of sulfonic group and hence the drug binding site in resin employed. The drug release was lower from the resins with higher degree of sulfonic group due to the increase in the diffusive path depth. The drug release was a little lower in stimulated gastric fluid (SGF) than stimulated intestinal fluids (SIF). The basic group, ionized to a little greater extent in SGF and preferred binding with the resin rather than releasing. Hence, the differently sulfonated resins could be utilized as novel carriers for drug delivery.


Keyword:     2-methacryloxyacetophenone methyl methacrylate different sulfonation cationic exchange resins valsartan in-vitro drug release.


Citation:

K. Doraswamy, V. Nagaraju, R. Srinivasulu and P. Venkata Ramana. Controlled drug release studies of valsartan using differently sulfonated methacryloxyacetophenone and methyl methacrylate co-polymer resins as drug carriers. J App Pharm Sci, 2013; 3 (11): 110-116.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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