Research Article | Volume: 3, Issue: 10, October, 2013

Magnetic and Compartmental Targeting of Azathioprine using Gelatin Microspheres: Formulation, Physicochemical Characterization and In Vitro Release Studies

Pinaparolu Devarajulu Arunkumar and Muniyandy Saravanan   

Open Access   

Published:  Oct 31, 2013

DOI: 10.7324/JAPS.2013.31004
Abstract

Azathioprine loaded gelatin microspheres were formulated to control/target drug release in an arthritic joint by magnetic force or intra-articular injection. Glutaraldehyde cross linked microspheres were characterized for drug loading, entrapment efficiency, gas chromatography, magnetite content, particle size, scanning electron microscopy (SEM), Fourier-Infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and in vitro release studies. The gelatin microspheres loaded with azathioprine showed 17% of drug loading with 82% of entrapment efficiency. Gelatin magnetic microspheres showed 13% of loading with 87% of entrapment efficiency. Gas chromatography confirms absence of residual glutaraldehyde in the microspheres. The magnetite content of the azathioprine loaded gelatin magnetic microsphere was 25.7% w/w. The average particle sizes of gelatin nonmagnetic and magnetic microspheres were 41 and 54 µm, respectively. SEM confirms the spherical nature of the microspheres. FT-IR revealed the absence of drug polymer interaction, and DSC suggested amorphous nature of entrapped drug in the microspheres. The formulated microspheres could release the drug over a period of 48 h.


Keyword:     Gelatin microspheres magnetic microspheres azathioprine intra-articular targeted drug delivery controlled drug delivery.


Citation:

Pinaparolu Devarajulu Arunkumar, Muniyandy Saravanan. Magnetic and Compartmental Targeting of Azathioprine using Gelatin Microspheres: Formulation, Physicochemical Characterization and In Vitro Release Studies. J App Pharm Sci, 2013; 3 (10): 017-022.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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