Short Communication | Volume: 3, Issue: 9, September, 2013

Effect of Artemisinin-Based Combination Therapy on some Selected Liver Function Indices of Pregnant Wistar Albino Rats

Ugian E.ADasofunjo K Nwangwa J.NAsuk A.AAkam M.SAjing E.NUgoanyanwu F.U.   

Open Access   

Published:  Sep 30, 2013

DOI: 10.7324/JAPS.2013.3926
Abstract

In the risk assessment of the effect of administration of artemisinin-based combination therapy on some selected liver function indices of pregnant wistar albino rats. Fifteen (15) pregnant wistar albino rats were divided into three groups and were allowed to acclimatize to laboratory condition for seven (7) days. Rats in group A served as the control and were administered with normal saline throughout the experimental period of seven (7) days, while rats in group B and C were administered intra-peritoneally with 3 and 6mg/kg body weight of artemisinin-based combination therapy respectively throughout the experimental period. Twenty four (24) hours after the last administration, the pregnant wistar albino rats were sacrificed. Blood was obtained by cardiac puncture for analysis of serum ALP, AST, ALT and bilirubin using standard methods and enzyme kits. The result showed that the drug at both 3and 6mg/kg body weight produced a significant (P<0.05) dosage increase in serum AST, ALT and ALP. The ratio of AST: ALT and AST: ALP showed a significant (P<0.05) increase. Similar pattern was also displayed by serum bilirubin concentration. These results are clear manifestations that artemisinin-based combination therapy might pose hepatic injury, hepatobilliary toxicity or complete hepatic damage in pregnant wistar albino rats. Thus, it is suggested that special precaution needs to be exercised on the usage of artemether-lumefantrine in pregnancy.


Keyword:     Artemisinin hepatic injury hepatic toxicity thera


Citation:

Ugian E.A, Dasofunjo K, Nwangwa J.N, Asuk A.A, Akam M.S,Ajing E.N, Ugoanyanwu F.U. , Effect of Artemisinin-Based Combination Therapy on some Selected Liver Function Indices of Pregnant Wistar Albino Rats. J App Pharm Sci. 2013; 3 (09): 152- 154.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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