Research Article | Volume: 3, Issue: 8, Supplement: 1, September, 2013

Herbal Hepatotoxicity: A Review on Phytochemical Induced Liver Injury

Prasad G. Jamkhandea Ganesh S. Tolsarwada Priti S. Tidkeb   

Open Access   

Published:  Aug 18, 2013

DOI: 10.7324/JAPS.2013.38.S16

Liver plays a key role in the metabolism and excretion of xenobiotics which makes it highly susceptible to their adverse and toxic effects. Drugs of synthetic origin are found to be major reason of liver toxicity but some herbs also contributes in same fashion. Various herbal medicines with a history of efficacy are effectively used by humans. However, owing to the presence of different phytoconstituents, which are found to be hepatotoxic, it is needed to focus on such phytochemicals. This review emphasizes some crucial aspects of phytoconstituents that produces hepatotoxicity and possible mechanism responsible for it.

Keyword:     Hepatotoxicity Lantadene Pyrrolizidine alkaloid Cycasin Cytotoxic cytochrome P450.


Prasad G. Jamkhande, Ganesh S. Tolsarwad, Priti S. Tidke., Herbal Hepatotoxicity: A Review on Phytochemical Induced Liver Injury. J App Pharm Sci. 2013; 3 ((8 Suppl 1): S106-S110.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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