Research Article | Volume: 3, Issue: 9, September, 2013

Therapeutic effects of standardized fenugreek seed extract on experimental urolithiasis in rats

Chinmay U. Kapase Subhash L. Bodhankar Vishwaraman Mohan Prasad A. Thakurdesai   

Open Access   

Published:  Sep 30, 2013

DOI: 10.7324/JAPS.2013.3906

The objective of the present study was to investigate therapeutic efficacy of standardized fenugreek seed extract with trigonelline as marker (SFSE-T) in experimental urolithiasis in rats. Effects of subacute oral treatments of SFSE-T (30 and 60 mg/kg) and reference anti-urolithiasis drug, Cystone (750 mg/kg) were evaluated against 0.75% ethylene glycol (EG) and 1 % w/v ammonium chloride (AC) induced urolithiasis in rats. The biochemical (urinary and serum) and histopathological parameters were investigated. Subacute oral treatment of SFSE-T (60 mg/kg) showed reversal of EG+AC induced changes in urine (decreased 24-h urine output, pH, excretion of creatinine, citrate, and chloride and increased uric acid and oxalate excretion) and serum (increased creatine, uric acid and blood urea nitrogen) parameters and decreased creatine clearance. Histopathology examination of the kidneys sections from SFSE-T (60 mg/kg) treated rats showed lowered number of crystals, cell damage and tubulointerstitial damage index as compared with EG+AC control rats. Standardized fenugreek seed extracts showed promising therapeutic effect against experimental urolithiasis in rats.

Keyword:     Fenugreek trigonelline therapeutic urolithiasis ethylene glycol calcium oxalate.


Chinmay U. Kapase, Subhash L., Bodhankar, Vishwaraman Mohan, Prasad A. Thakurdesai., Therapeutic effects of standardized fenugreek seed extract on experimental urolithiasis in rats. J App Pharm Sci, 2013; 3 (09): 029-035.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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