Research Article | Volume: 3, Issue: 9, September, 2013

The role of Qualea multiflora on Mammary Tumour Cells and Immune System

Camila B. de A. Carlia Marcela Bassi Quillesa Wagner Vilegasb and Iracilda Z. Carlosa   

Open Access   

Published:  Sep 30, 2013

DOI: 10.7324/JAPS.2013.3902
Abstract

Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-α) and the transcription factor NF-kB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-α; about 32% of NF-kB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.


Keyword:     Cancer Macrophages Q. multiflora.


Citation:

Camila B. de A. Carli, Marcela Bassi Quilles, Wagner Vilegas, and Iracilda Z. Carlos., The role of Qualea multiflora on Mammary Tumour Cells and Immune System. J App Pharm Sci, 2013; 3 (09): 008-013.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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