Research Article | Volume: 3, Issue: 8, Supplement: 1, September, 2013

Comparative Screening analysis of Natural metabolites against a cholera toxin

R. Balajee and M.S.Dhana Rajan   

Open Access   

Published:  Sep 18, 2013

DOI: 10.7324/JAPS.2013.38.S12
Abstract

Cholera is one of the earliest infections to be studied by epidemiological methods. Worldwide it affects 3-5 million people and causes 100,000-130,000 deaths a year as of 2010. Cholera is an infection of the small intestine that causes a large amount of watery diarrhea; it is caused by the bacterium vibrio cholerae. The cholera toxin (CTX or CT) is an oligomeric complex made up of six protein subunits a copy of A subunit and the five copies of B subunit, connected by a disulfide bond. This study is based on targeting the CTX using computational tools, a natural metabolite mangiferin was taken and its chemical features are generated using common pharmacophore analysis, using minmaybridge database and taken lead compound were optimized and the Lipinski’s Rule of 5 properties were analyzed. Here, the binding affinity of protein – ligand interaction studied and displayed using ligand fit.


Keyword:     Cholera CTX Mangiferin pharmacophore similar compounds Docking pharmacophoric analysis.


Citation:

R. Balajee and M.S. Dhana Rajan. Comparative screening analysis of Natural metabolites against a cholera toxin. J App Pharm Sci. 2013; 3 (8 Suppl 1): S75-S78.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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