Research Article | Volume: 3, Issue: 8, August, 2013

Antileishmanial, Antimalarial and Antimicrobial activity of the Jamaican ‘Touch-me-not’ sponge Neofibularia nolitangere

Monique N. Thompson and Winklet Gallimore   

Open Access   

Published:  Aug 30, 2013

DOI: 10.7324/JAPS.2013.3814
Abstract

The crude extracts and fractions of the Jamaican sponge Neofibularia nolitangere were examined for biological activity. The dried animal was extracted successively in three organic solvents (hexane, methylene chloride and methanol) and tested for their potential as antileishmanial, antimalarial and antimicrobial agents. Fractions of the crude methylene chloride extract demonstrated notable antimalarial properties giving percentage inhibitions of 87% and 78% respectively for fractions Y4 and Y5 at 20 μg/mL. Fractions Y4 and Z4 showed remarkable antileishmanial activity inhibiting the growth of the pathogen by 93.31% and 91.77% respectively at 20 μg/mL. No significant activity was observed in the antimicrobial assays.


Keyword:     Neofibularia nolitangere antilei


Citation:

Monique N. Thompson and Winklet Gallimore. Antileishmanial, Antimalarial and Antimicrobial activity of the Jamaican ‘Touchme-not’ sponge Neofibularia nolitangere. J App Pharm Sci, 2013; 3 (08): 080-083.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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