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Volume: 3, Issue: 6, June, 2013
DOI: 10.7324/JAPS.2013.3617



Research Article

Design of dissolution media for in-vitro bioequivalence testing of Lamivudine

Nagiat T Hwisa1, Shanta Kumari Adiki2, Prakash Katakam1, Babu Rao Chandu1

  Author Affiliations


Abstract

The present investigation is aimed at developing the stability indicating dissolution media for the determination of lamivudine (3TC) in pharmaceutical dosage forms. The stability of 3TC was tested in various dissolution media maintained at ambient temperature and 37 oC for 48 hrs. Stability studies of 3TC in various media indicated that the drug was stable in 0.1M HCl, pH 1.2 KCl-HCl buffer, pH 6.2 and pH 7.0 phosphate buffers. The ╬╗max were found to be 280.0, 278.8, 273.0 and 271.5nm for 0.1M HCl, pH 1.2 KCl-HCl buffer, pH 6.2 and pH 7.0 phosphate buffers respectively with low CV of

Keywords:

Lamivudine, Stability indicating, Bioequivalence studies, Dissolution media.



Citation: Nagiat T Hwisa, Shanta Kumari Adiki, Prakash Katakam, Babu Rao Chandu. Design of dissolution media for in-vitro bioequivalence testing of Lamivudine. J App Pharm Sci, 2013; 3 (06): 106-110.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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