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Volume: 3, Issue: 1, January, 2013
DOI: 10.7324/JAPS.2013.30102

Research Article

Evaluation of Physical and Chemical Stability of Nanostructured Lipid Carries Containing Ursolic Acid in Cosmetic Formulation

Almeida, Mariana Mandelli1, Bou-Chacra, Nádia A1, Conte, Juliana Denise1, Kaneko, Telma Mary1, Baby, André Rolim1, Velasco, Maria Valéria Robles1

  Author Affiliations


The new generation of lipid nanoparticles with solid matrix are the NLC (Nanostructured lipid carriers), and these nanoparticles show increased chemical stability of drug, film formation, controlled occlusion, increased skin hydration, the bioavailability of the active skin is improved, increase the physical stability of lipid nanoparticles in topical formulations and lower toxicity. The NLC were produced by the technique of High Pressure Homogenization (HPH). The Accelerated Stability Test, also known as Normal Stability or exploratory, aims to provide data to predict product stability, shelf life and formulation compatibility with the packaging material. Therefore, this study aims: to evaluate the normal stability under varying conditions of temperature and luminosity over time as their physical and chemical characteristics in cosmetic formulation containing ursolic acid in free and nanoparticle forms. Based on the results, the ursolic acid in the nanostructured lipid carrier form achieved a better physical and chemical stability compared to ursolic acid in the free form in both variation of the viscosity and pH.


Ursolic acid, stability, Nanostructured lipid carriers, cosmetic formulation.

Citation: Almeida, Mariana Mandelli; Bou-Chacra, Nádia A; Conte, Juliana Denise; Kaneko, Telma Mary; Baby, André Rolim; Velasco, Maria Valéria Robles. Evaluation of physical and chemical stability of nanostructured lipid carries containing ursolic acid in cosmetic formulation. J App Pharm Sci. 2013; 3 (01): 005-008.

Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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